UniProt MCP server
Verifiable, release-aware protein evidence workflows over UniProt and linked scientific sources.
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3 stars372 downloads/wk
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If you have run it, two minutes of your experience saves the next person an afternoon.
UniProt MCP tools
No tool declarations could be read from the package source. They show once the server is installed.
How UniProt MCP compares
Against every graded MCP server, from our own scans and uptime checks. Updated after each scan run.
- Safety score
- 92/100
- higher than 93% of 48,243 servers
- GitHub stars
- 3
- more than 80% of 28,706 servers
- Downloads a week
- 372
- more than 84% of 12,306 servers with a package
Release history: 9 versions in the registry since 2026-09-03, latest 2026-11-04, typically one every 8 days.
Install UniProt MCP in Claude Code, Cursor or VS Code
claude mcp add uniprot-mcp -- uvx uniprot-mcp-server
What the publisher says
From the UniProt MCP repository's README, as published. We do not edit it. Read it on GitHub
<!-- mcp-name: io.github.smaniches/uniprot-mcp -->
UniProt MCP Server
Produce verifiable, release-aware protein evidence packages from UniProt and linked scientific sources.
Use this MCP server to find proteins, assemble protein, target, and variant evidence, and keep a checkable record of where each result came from. Each successful response records the UniProt release, retrieval time, resolved source URL, and a SHA-256 digest. uniprotprovenanceverify can later determine whether the upstream record is unchanged or has drifted.
The complete tool catalog remains available for specialized research workflows.
Author: Santiago Maniches · ORCID 0009-0005-6480-1987 · TOPOLOGICA LLC
Run it in one line:
uvx uniprot-mcp-serverVerifiable provenance (the receipts)
Every answer this server returns is traceable to a primary-source URL and a content hash you can re-compute yourself. The walkthrough below is a real run against the live server (UniProt release 2026_01), independently confirmed against the UniProt REST API.
Question. What is the function of human p53 (UniProt P04637), what heritable cancer syndrome is it associated with, and is the R175H mutation a documented disease variant?
Answer, with its provenance footer (verbatim from the server):
393 aa). "Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis... Acts as a tumor suppressor in many tumor types."
- Function. Cellular tumor antigen p53 (gene TP53, Homo sapiens,
DI-01904, OMIM 151623) — "an autosomal dominant familial cancer syndrome... Four types of cancers account for 80% of tumors occurring in TP53 germline mutation carriers."
- Disease. Li-Fraumeni syndrome (acronym LFS, UniProt disease id
somatic mutation; does not induce SNAI1 degradation; reduces interaction with ZNF385A; dbSNP:rs28934578."
- Variant. R175H — "in LFS; germline mutation and in sporadic cancers;
Shortened. The full README is on GitHub.
Nothing above is checked by us. What we check is on the safety report.
UniProt MCP: common questions
- Is UniProt MCP server safe?
- Yes, by our scan: it is graded A (92/100). Read the UniProt MCP safety report
- How do I install UniProt MCP?
- It runs on your machine. Copy the Claude Code, Cursor, VS Code or Claude Desktop config from the install section.
- Does UniProt MCP need an API key?
- Not as far as the registry entry and our scan can tell: no credentials are declared or required.
- Is UniProt MCP maintained?
- The last commit was 21 days ago (2026-10-15). The latest release is v1.3.17.
- How does UniProt MCP compare with other MCP servers?
- safety score 92/100 (higher than 93% of 48,243 servers); github stars 3 (more than 80% of 28,706 servers); downloads a week 372 (more than 84% of 12,306 servers with a package). Full comparison.