Inxight Drugs MCP server

@pipeworx/inxight-drugs

Drug development status by indication from NCATS Inxight Drugs: for any drug or substance, the conditions it is approved for or in trials for, the highest phase reached per condition, its approval history, originator and targets.

Part of Pipeworx — an MCP gateway connecting AI agents to 1764+ live data sources. This is an independent, unofficial integration — not affiliated with, endorsed by, or published by the upstream provider.

Tools

indication with its highest phase (Approved / Phase III / II / I) and the trial or label URL behind it, the overall highest development event, first approval year, originator, targets with pharmacology and potency, synonyms, and ChEMBL / DrugBank / PubChem / CAS / MeSH / RxCUI ids. Answers "what is psilocybin being developed for, and how far along".

• inxight_substance(name | unii) — one substance by name or FDA UNII: every

substance search; returns UNIIs plus breakdowns of the hits by development status, highest phase and condition.

• inxightsearch(query, developmentstatus?, limit?, offset?) — free-text

substances for a disease, each with the highest phase reached FOR THAT condition. development_status: "Clinical" keeps only investigational drugs. Also returns the related condition labels Inxight uses ("Ischemic stroke", "Acute ischemic stroke") for drilling down.

• inxightindication(condition, developmentstatus?, limit?, offset?) —

An unknown drug or condition returns found: false with a reason and a hint; an upstream HTTP error throws.

For mechanism of action and target-disease evidence, use the chembl and opentargets packs — inxight_substance returns the ChEMBL id to hop across. For individual trials, use clinicaltrials.

Auth

Keyless.

Data sources

Inxight Drugs () is run by NIH's National Center for Advancing Translational Sciences. It is a GSRS deployment that joins the FDA Global Substance Registration System with ClinicalTrials.gov, DrugBank, Drugs@FDA, DailyMed and orphan designations. The site is an Angular app; the JSON API it calls is public but undocumented. Endpoints used, all GET:

Exact-name match is q=rootnamesname:"^PSILOCYBIN$"; UNII lookup is q=rootapprovalID:"2RV7212BP0". Filter with repeated facet=/, e.g. facet=Condition/Stroke and facet=Development Status/Clinical (facets AND together). — the condition labels containing a string, with counts. Facet values are case-sensitive, so inxightindication resolves the caller's text here first.

• — search.

and code cross-references.

• https://drugs.ncats.io/api/v1/substances()?view=full — names

Inxight layer: a flat list of {name, value} records. The ones used are Conditions (per-indication highestPhase + highestPhaseUri), Targets, Stitcher Highest Phase, Highest Development Event, Earliest Approved Event, Approval Year, Originator, Description.

• https://drugs.ncats.io/api/v1/substances()/@additional — the

Things worth knowing:

string"), not 404 — which is why UNII lookup goes through search instead.

• An unrecognized id in substances() answers HTTP 500 ("Invalid UUID

re-sorts the page it fetched by phase for the condition.

• Conditions always carries a placeholder row labelled Unknown; it is dropped.
• Search order is the upstream's, not relevance or phase. inxight_indication

records say e.g. "ClinicalTrials, February 2021"), so a programme that moved phase recently can read one phase behind. Check clinicaltrials for the latest trial.

• Condition phases come from a ClinicalTrials.gov snapshot (the Stitcher Label

Quick Start

Shortened. The full README is on GitHub.